Open date: August 23, 2022
Next review date: Saturday, Oct 15, 2022 at 11:59pm (Pacific Time)
Apply by this date to ensure full consideration by the committee.
Final date: Tuesday, Aug 22, 2023 at 11:59pm (Pacific Time)
Applications will continue to be accepted until this date, but those received after the review date will only be considered if the position has not yet been filled.
The Department of Molecular Biology in the School of Biological Sciences (https://biology.ucsd.edu/) is conducting an open search for Project Scientists (non-tenured, Assistant, Associate or Full level). At UC San Diego, Project Scientists are academic researchers who are expected to make significant and creative contributions to a research team but are not necessarily leaders of the research team. They are not required to carry out independent research or develop an independent research reputation but will publish and carry out research or creative programs with supervision by a member of the Professor or Professional Research series. University and public service are encouraged but not required and they do not have formal teaching responsibilities. Appointments and duration vary depending on the length of the research project and availability of funding.
The School of Biological Sciences at UCSD is a vibrant center of scientific discovery, innovation, and collaboration. Our large research base spans many areas of biology. We are committed to academic excellence and diversity within the faculty, staff, and student body.
Salary is commensurate with qualifications and based on University of California pay scales.
Please submit all required materials to: https://apol-recruit.ucsd.edu/JPF03298
All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran.
This research project is focused on how eukaryotic cells handle non-genomic stress. Specifically, how the Endoplasmic Reticulum (ER) responds to cellular stress such as increased demands for secretory protein or lipid production brought on by environmental challenge, injury or disease. This project focuses on the multi-dimensional Unfolded Protein Response (UPR) signaling pathway in normal and disease states. We are focused on understanding the first cell cycle checkpoint that monitors the ER, termed the ER Surveillance Checkpoint (ERSU). The ERSU checkpoint ensures that the size and functional capacities of the ER expand to meet the challenge of supplying two dividing cells during the cell cycle. We are investigating how ER stress pauses this cell cycle progression machinery, using molecular and cellular approaches in both yeast and mammalian models.
We are further studying inter-organellar communication between the ER and the cell nucleus, in a new project geared to understanding the architectural and functional coordination between these vital organelles and how they change under stress. This is critically important in mammalian cells as the ER and nuclear membranes are contiguous at multiple contact points and, at the onset of mitosis, the nuclear envelope (NE) breaks down and all the integral nuclear membrane proteins move into the ER. Later, as nuclear membranes reform at the end of mitosis, the integral nuclear membrane proteins must be preferentially retrieved from the ER. Overall, failure of the ER to meet one or more of the challenges detailed above is an underlying cause of many human diseases, including cancers and neurodegenerative disease. Therefore, we also use normal and disease models to dissect how the failure of the ER to make the needed changes in response to different stressors leads to human disease.
All candidates must have earned a Ph.D. or equivalent degree in Molecular Biology or related field.
Preferred qualifications include postdoctoral or equivalent experience, a commitment to a research program, experience and interest in mentoring/training, and a commitment to building an equitable and diverse scholarly environment.
Curriculum Vitae - Your most recently updated C.V.
Statement of Research
Statement of Contributions to Diversity - Applicants should summarize their past or potential contributions to diversity. See our Faculty Equity site for more information.
Publication 3 (Optional)
Misc / Additional (Optional)
- 3-5 letters of reference required
Help contact: firstname.lastname@example.org
The University of California, San Diego is an Equal Opportunity/Affirmative Action Employer advancing inclusive excellence. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, covered veteran status, or other protected categories covered by the UC nondiscrimination policy.
As a condition of employment, you will be required to comply with the University of California SARS-CoV-2 (COVID-19) Vaccination Program Policy. All Covered Individuals under the policy must provide proof of Full Vaccination or, if applicable, submit a request for Exception (based on Medical Exemption, Disability, and/or Religious Objection) or Deferral (based on pregnancy) no later than the applicable deadline. Please refer to Appendix F, Section II.C. of the policy for the deadlines applicable to new University of California employees. (Capitalized terms in this paragraph are defined in the policy.) Federal, state, or local public health directives may impose additional requirements.
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